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KMID : 1146620160050020061
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Journal of Korean Academy of Advanced General Dentistry
2016 Volume.5 No. 2 p.61 ~ p.66
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Histomorphometric Study of New Bone Formation Around Immediately Placed Titanium Implant on the Extraction Socket of Diabetic and Insulin Treated Rat
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Kim Sung-MIn
Park Su-Hyun
Heo Hyun-A
Pyo Sung-Woon
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Abstract
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Introduction: Dental implants are routinely used with high success rates in generally healthy individuals. By contrast, their use in patients with diabetes mellitus remains controversial as altered bone healing around implants has been reported. The present study aimed to investigate the bone healing response around immediately placed titanium implants in the rats with controlled and uncontrolled diabetes.
Materials and Methods: Twenty rats were divided into the control, insulin-treated and diabetic groups. The rats received streptozotocin (60 mg/kg) to induce diabetes; animals in the insulin-treated group also received three units of subcutaneous slow-release insulin. A titanium implant (1.2×3 mm) was placed in the extraction socket of the maxillary
first molar and was harvested at 2 and 4 weeks. After routine process of histologic process, section were measured for
Bone-implant contact, bone density using Image analysis program.
Results: After 2 weeks post-implantation, BCR (Bone contract ratio) of the control, the diabetic group and insulintreated group was 42.62%, 24.55% and 27.75%, respectively. The BCR of the control was lower than the diabetic group and insulin-treated group. After 4 weeks post-implantation, BCR (Bone contract ratio) of the control, the diabetic group and insulin-treated group was 45.32%, 39.14% and 43.84%, respectively. Also, the results of bone density was showed a similar pattern of the results of BCR.
Conclusion: The immediate placement of titanium implants in the maxilla of controlled diabetic rat led to a wanted bone healing response. In conclusion, the results of this study suggest that immediate implant insertion in patients with controlled diabetes might be indicated.
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KEYWORD
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Diabetes mellitus, Dental implants, Insulin, Bone formation, Osseointegration
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